Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-difluoromethylornithine | i.e. DFMO, ODC inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma, inhibition of ODC by DFMO promotes cell survival by inducing the phosphorylation of Akt/PKB at residue Ser473 and glycogen synthase kinase-3B at Ser9, DFMO also induces the phosphorylation of p27Kip1 at residues Ser10, involved in nuclear export, and Thr198, involved in protein stabilization, but not Thr187, involved in proteasomal degradation,inhibition mechanism, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | Homo sapiens | ODC is a key enzyme in mammalian polyamine biosynthesis that is up-regulated in various types of cancer | putrescine + CO2 | - |
? | |
additional information | Homo sapiens | ODC inhibition by alpha-difluoromethylornithine, and following polyamine depletion, activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LAN-1 cell | a human NB cell line | Homo sapiens | - |
neuroblastoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | - |
Homo sapiens | putrescine + CO2 | - |
? | |
L-ornithine | ODC is a key enzyme in mammalian polyamine biosynthesis that is up-regulated in various types of cancer | Homo sapiens | putrescine + CO2 | - |
? | |
additional information | ODC inhibition by alpha-difluoromethylornithine, and following polyamine depletion, activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODC | - |
Homo sapiens |